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09:24 Aug 30, 2014 |
English to Dutch translations [PRO] Medical - Medical: Pharmaceuticals / Octrooiaanvraag mab | |||||||
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| Selected response from: Barend van Zadelhoff Netherlands Local time: 23:46 | ||||||
Grading comment
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Summary of answers provided | ||||
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3 +1 | oorspronkelijke immunoglobuline; Fc-regio van het oorspronkelijke immunoglobuline |
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Discussion entries: 2 | |
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parent immunoglobulin; parent fc region oorspronkelijke immunoglobuline; Fc-regio van het oorspronkelijke immunoglobuline Explanation: 'original' en 'parent' worden door elkaar gebruikt A single-chain variable fragment (scFv) is not actually a fragment of an antibody, but instead is a fusion protein of the variable regions of the heavy (VH) and light chains (VL) of immunoglobulins, connected with a short linker peptide of ten to about 25 amino acids. The linker is usually rich in glycine for flexibility, as well as serine or threonine for solubility, and can either connect the N-terminus of the VH with the C-terminus of the VL, or vice versa. This protein retains the specificity of the original immunoglobulin, despite removal of the constant regions and the introduction of the linker. The image to the right shows how this modification usually leaves the specificity unaltered. http://www.quickiwiki.com/en/Single-chain_variable_fragment The variable regions of the heavy and light chains can be fused together to form a single-chain variable fragment (scFv), which is only half the size of the Fab fragment, yet retains the original specificity of the parent immunoglobulin http://www.quickiwiki.com/en/Fragment_antigen-binding zie verder discussie -------------------------------------------------- Note added at 1 hr (2014-08-30 10:47:48 GMT) -------------------------------------------------- Overigens kan "Fc-fragment" of "Fc-deel" ook worden gebruikt. Ik zou "Fc-fragment" gebruiken. -------------------------------------------------- Note added at 1 hr (2014-08-30 10:52:05 GMT) -------------------------------------------------- Of, als de context het toelaat: "oorspronkelijke Fc-fragment" i.p.v. "Fc-fragment van het oorspronkelijke immunoglobuline" |
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