affinity maturation

French translation: maturation d'affinité

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00:55 Oct 28, 2020
English to French translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals
English term or phrase: affinity maturation
Definition from Johns Hopkins Medicine:
the process through which B cells mature and produce antibodies that have a greater affinity for their antigenic target. This process is more prominent when the immune response is well under way.

Example sentence(s):
  • Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. Frontier in Immunology
  • An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. ScienceDirect
  • We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny PNAS
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French translation:maturation d'affinité
Definition:
Augmentation progressive des affinités des anticorps pour l'antigène lors d'expositions successives à l'antigène.

Dictionnaire des sciences de la vie
De Romaric Forêt
Selected response from:

Gladis Audi, DipTrans
Netherlands
Grading comment
4 KudoZ points were awarded for this answer



Summary of translations provided
4 +2maturation d'affinité
Gladis Audi, DipTrans
4maturation de l'affinité des anticorps
Mélika El Younsi


  

Translations offered


4 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +2
maturation d'affinité


Definition from Dictionnaire des sciences de la vie :
Augmentation progressive des affinités des anticorps pour l'antigène lors d'expositions successives à l'antigène.

Dictionnaire des sciences de la vie
De Romaric Forêt

Example sentence(s):
  • - - - 

Explanation:
Elle est due à deux processus qui ont lieu dans les centres germinaux des organes lymphoides secondaires:
- l'hypermutation somatique
- la sélection clonale
Gladis Audi, DipTrans
Netherlands
Local time: 15:20
Native speaker of: French
PRO pts in category: 24

Votes in favor of/against selecting this as the best translation of the term asked
Yes  Lionel-N: https://fr.wikipedia.org/wiki/Maturation_d'affinité_des_immu...'affinit%C3%A9%20est,affinit%C3%A9%20croissante%20pour%20l'antig%C3%A8ne.
10 days
  -> Merci bien :)

Yes  François Tardif
11 days
  -> Merci
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9 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
maturation de l'affinité des anticorps


Definition from own experience or research:
Procédé au décours duquel les cellules B produisent des anticorps spécifiques aux antigènes cibles

Example sentence(s):
  • La maturation de l’affinité des anticorps au cours de la réponse immunitaire correspond à la sélection, dans la population des lymphocytes B à mémoire, des cellules présentant la meilleure affinité contre l’agent infectieux, ce qui permettra une réponse plus rapide et plus efficace lors d’une nouvelle rencontre avec ce pathogène. - Inserm Ipubli  
Mélika El Younsi
France
Local time: 15:20
Native speaker of: Native in FrenchFrench
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