switch control kinase inhibitor
Italian translation: inibitore del controllo di switch della chinasi
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| 10:40 Nov 12, 2020 |
| English to Italian translations [PRO] Medical - Biology (-tech,-chem,micro-) / annulus cushion base | |||||||
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|  Selected response from: Gaetano Silvestri Campagnano Italy Local time: 11:57 | ||||||
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| 4 | inibitore del controllo di switch della chinasi |
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49 mins confidence: 
inibitore del controllo di switch della chinasi Explanation: Ciao Vincenzo. Ecco un riferimento in inglese che spiega il processo di inibizione: https://www.gistsupport.org/ask-the-professional/switch-pock... "The “switch pocket” is an area on KIT and other kinases that is adjacent to the ATP pocket. The “switch pocket” binds to the activation loop which acts as the major “on-off switch” of a kinase. The kinase will be active or “on” when the “activation loop switch” is bound to the “switch pocket”. By preventing the “switch” from binding to the “switch pocket,” a switch pocket inhibitor can prevent a kinase from turning “on” or can even turn “off” an already active kinase." -------------------------------------------------- Note added at 50 min (2020-11-12 11:30:55 GMT) -------------------------------------------------- Agisce in pratica su questa sorta di "interruttore" proteico della chinasi. -------------------------------------------------- Note added at 51 min (2020-11-12 11:32:09 GMT) -------------------------------------------------- Ecco un altro riferimento: https://www.deciphera.com/science/our-kinase-switch-control-... "Our proprietary drug discovery Kinase Switch Control platform is based on our deep insight into the biology of kinases. The transformation of a kinase from an inactive to an activated state is dependent upon the interaction of one region of the kinase called the activation switch with an area called the switch pocket; a mechanism of activation that is common among kinases. By directly targeting the switch pocket, we design inhibitors to be broadly active against the target kinase, covering both wild-type and many or all of the known mutant or amplified forms, or spectrum-selective towards several chosen kinases." -------------------------------------------------- Note added at 56 min (2020-11-12 11:37:15 GMT) -------------------------------------------------- Puoi anche scrivere: inibitore dell'interruttore della chinasi "" -------------------------------------------------- Note added at 57 min (2020-11-12 11:37:45 GMT) -------------------------------------------------- Con o senza virgolette. -------------------------------------------------- Note added at 1 ora (2020-11-12 11:50:23 GMT) -------------------------------------------------- Ecco un riferimento in italiano: https://blog.farmaciavirtuale.it/2013/11/inibitori-delle-chi... "In questo articolo commenteremo, in via generale, l’attività degli inibitori delle tirosin e serin/treonin chinasi. Volendo semplificare il concetto di chinasi, potremmo descriverle come enzimi ATP dipendenti, che funzionano da interruttori della cellula." -------------------------------------------------- Note added at 7 giorni (2020-11-19 12:43:18 GMT) Post-grading -------------------------------------------------- Grazie mille a te, Vincenzo. A presto e buona giornata! |
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