Full target saturation

00:15 Dec 2, 2020
English to Spanish translations [PRO]
Medical - Medical: Pharmaceuticals / Clinical Protocol
English term or phrase: Full target saturation
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Pharmacology data showing full target saturation in both systemic circulation (inferred from PK data) and tumor (inferred from PBPK analysis) at 200 mg Q3W


Gracias!!!
Carina Brizuela


Summary of answers provided
4 +1saturación total del objetivo
Paulo Gasques
3saturación de la unión del fármaco con la diana receptora
Chema Nieto Castañón


  

Answers


2 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
saturación total del objetivo


Explanation:
Considerando el contexto lo haria de esta manera,

Saludos

Paulo Gasques
Mexico
Local time: 22:51
Native speaker of: Native in PortuguesePortuguese
PRO pts in category: 4

Peer comments on this answer (and responses from the answerer)
agree  Pablo Cruz
210 days
  -> Gracias, que tengas un excelente y bendecido dia.
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10 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
saturación de la unión del fármaco con la diana receptora


Explanation:
El concepto de saturación, sin otra referencia, creo que podría inducir a equívoco. Se refiere aquí específicamente a que se alcanza la saturación de la unión del fármaco con la diana receptora, esto es, que a las dosis planteadas no hay receptores libres -sin fármaco- a nivel plasmático o tumoral.

Ver pej.,

La característica principal de un modelo TMDD, y responsable de que la PK del fármaco sea no lineal es la saturación de la unión del fármaco con la diana receptora debida a
la alta afinidad del ligando con el fármaco.
https://www.google.com/url?sa=t&source=web&rct=j&url=https:/...


Chema Nieto Castañón
Spain
Local time: 06:51
Specializes in field
Native speaker of: Native in SpanishSpanish
PRO pts in category: 553
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