gut durchreifend

English translation: with good maturation status/well-matured

10:36 May 1, 2019
German to English translations [PRO]
Medical - Biology (-tech,-chem,micro-) / Bone marrow analysis
German term or phrase: gut durchreifend
I am just wondering if this is an evolving state or a past state. So "maturing well" or "well-matured"?

The sentence examples are:


Die Erythropoiese ist relativ und absolut gut vertreten, gut durchreifend bis zum oxiphilen Erythroblasten.

Die Myelopoiese ist relativ und absolut normal vertreten, gut durchreifend bis zum segmentkernigen Granulozyten.

Many thanks!
Leila Howden
United Kingdom
Local time: 16:35
English translation:with good maturation status/well-matured
Explanation:

I understand here that myelopoiesis goes through a normal process of maturation up to the point of forming granulocytes.

Myelopoiesis (granulopoiesis) involves a series of maturational steps leading to the formation of granulocytes, including neutrophils, eosinophils, and basophils (Figure 15).
https://www.sciencedirect.com/topics/immunology-and-microbio...

GRANULOID CELLS
the stage preceding the pmn in maturation

MATURATION SEQUENCE
https://www.kau.edu.sa/Files/0001746/files/4880_MYELOPOIESIS...

The unique myelocyte next differentiates into a metamyelocyte and then a band cell, with a "C" shaped nucleus, before becoming a mature eosinophil, basophil, or neutrophil. Macrophages come from monoblast progenitors that differentriate into promonocytes, which mature into monocytes.
https://www.definitions.net/definition/myelopoiesis

Other enhancers seem to be important for neutrophil development as well, but at later stages of maturation
http://www.bloodjournal.org/content/129/15/2083?sso-checked=...

To determine the maturation status of the bone marrow granulocytes
http://www.jimmunol.org/content/186/2/1032
Selected response from:

Stuart and Aida Nelson
United Kingdom
Local time: 16:35
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +2with good maturation status/well-matured
Stuart and Aida Nelson
4all cell lines represented
Lirka
Summary of reference entries provided
The previous question ...
Steffen Walter

Discussion entries: 2





  

Answers


1 hr   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +2
with good maturation status/well-matured


Explanation:

I understand here that myelopoiesis goes through a normal process of maturation up to the point of forming granulocytes.

Myelopoiesis (granulopoiesis) involves a series of maturational steps leading to the formation of granulocytes, including neutrophils, eosinophils, and basophils (Figure 15).
https://www.sciencedirect.com/topics/immunology-and-microbio...

GRANULOID CELLS
the stage preceding the pmn in maturation

MATURATION SEQUENCE
https://www.kau.edu.sa/Files/0001746/files/4880_MYELOPOIESIS...

The unique myelocyte next differentiates into a metamyelocyte and then a band cell, with a "C" shaped nucleus, before becoming a mature eosinophil, basophil, or neutrophil. Macrophages come from monoblast progenitors that differentriate into promonocytes, which mature into monocytes.
https://www.definitions.net/definition/myelopoiesis

Other enhancers seem to be important for neutrophil development as well, but at later stages of maturation
http://www.bloodjournal.org/content/129/15/2083?sso-checked=...

To determine the maturation status of the bone marrow granulocytes
http://www.jimmunol.org/content/186/2/1032


Stuart and Aida Nelson
United Kingdom
Local time: 16:35
Works in field
Native speaker of: Native in EnglishEnglish, Native in SpanishSpanish
PRO pts in category: 4
Notes to answerer
Asker: Thank you this is very helpful :)


Peer comments on this answer (and responses from the answerer)
agree  Steffen Walter: convincing examples
1 hr
  -> Thank you, Stefen:)

agree  Ramey Rieger (X)
2 hrs
  -> Thank you, Ramey.
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2 days 3 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
all cell lines represented


Explanation:
HTH

Lirka
Austria
Local time: 17:35
Specializes in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 39
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Reference comments


18 mins
Reference: The previous question ...

Reference information:
... at https://www.proz.com/kudoz/german-to-english/medical-general... might be helpful.

Note that you erroneously entered "durchgreifend" in the question headline - I've asked the moderator to edit the term.

--------------------------------------------------
Note added at 20 mins (2019-05-01 10:56:34 GMT)
--------------------------------------------------

On a more general note, this term appears to refer to the current state (i.e. the state at the time of the lab test) despite its usage/word formation because the analysis delivers but a "snapshot", rather than describing a process.

Steffen Walter
Germany
Native speaker of: Native in GermanGerman
PRO pts in category: 27
Note to reference poster
Asker: Thanks Steffen, sorry for the typo! Yes durchreifend is what I wanted

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