May 7, 2014 17:29
10 yrs ago
4 viewers *
English term
a compound symmetry covariance structure
English to Russian
Medical
Mathematics & Statistics
clinical trials
context: "For the superiority comparison of XXXX 100 mcg twice daily versus placebo, assuming that the change from baseline in trough FEV1 over the 12-week treatment period is analyzed using a mixed model for repeated measures (MMRM) with fixed effects of treatment, time, and treatment-by-time interaction and with ***a compound symmetry covariance structure**** for the repeated observations within a patient, that a true time-averaged (ie, averaged over 12 weeks) treatment difference is 130 mL between XXXX 100 mcg twice daily and placebo, that a common standard deviation is 330 mL, that there are 8 repeated postbaseline assessments of trough FEV1 for each patient, and that a correlation coefficient is 0.7 among repeated observations within a patient, 100 patients per treatment group (a total of 500 patients) will yield an approximate statistical power of 90%, at a significance level of 0.05, for the 2-sided superiority test of XXXX 100 mcg twice daily versus placebo."
FEV1 is forced expiratory volume in 1 second
FEV1 is forced expiratory volume in 1 second
Proposed translations
(Russian)
3 | составная симметричная ковариационная структура | sas_proz |
3 | составная симметрия ковариационной структуры | Andrey Svitanko |
Proposed translations
22 mins
составная симметричная ковариационная структура
23 mins
Discussion