Glossary entry (derived from question below)
Polish term or phrase:
pozbawienie genu
English translation:
gene knockout/inactivation of a gene
Added to glossary by
Frank Szmulowicz, Ph. D.
Aug 13, 2015 14:51
8 yrs ago
1 viewer *
Polish term
pozbawienie genu
Polish to English
Science
Genetics
general
"PLP jest ważnym czynnikiem biorącym udział w powstawaniu wielowarstwowej, upakowanej struktury mieliny. Badania wykazały, że pozbawienie genu dla PLP (u myszy) wpływa na powstawanie patologii w zakresie osłonki mielinowej."
"PLP gene knockout (in mice)"?
"PLP gene knockout (in mice)"?
Proposed translations
(English)
| 3 +3 | loss of a gene |
Frank Szmulowicz, Ph. D.
|
| 2 | lacking the gene |
liz askew
|
Change log
Aug 24, 2015 22:07: Frank Szmulowicz, Ph. D. Created KOG entry
Proposed translations
+3
14 mins
Frank Szmulowicz, Ph. D.
United States
United States
Native in Polish
&
English
United States
On time, on target, on budget.
Native in: English 
, Polish
Works in: Polish to English, English to Polish, Russian to Polish, and 1 more.
Related KudoZ points
:
4
Selected
loss of a gene
Yes, gene knockout is another term.
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Note added at 20 mins (2015-08-13 15:11:41 GMT)
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Option 2removal of a gene
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Note added at 9 hrs (2015-08-13 23:56:22 GMT)
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option 3: inactivation of a gene
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Gene knockout: loss of a gene can be compensated by another gene
http://www.mpg.de/9331068/knockout-knockdown
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A knockout mouse or knock-out mouse is a genetically modified mouse in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity often causes changes in a mouse's phenotype, which includes appearance, behavior and other observable physical and biochemical characteristics.
The loss of gene activity often causes changes in a mouse's phenotype, which includes appearance, behavior and other observable physical and biochemical
https://en.wikipedia.org/wiki/Knockout_mouse
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What is a knockout mouse?
A knockout mouse is a laboratory mouse in which researchers have inactivated, or "knocked out," an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity often causes changes in a mouse's phenotype, which includes appearance, behavior and other observable physical and biochemical characteristics.
https://www.genome.gov/12514551
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Note added at 20 mins (2015-08-13 15:11:41 GMT)
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Option 2removal of a gene
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Note added at 9 hrs (2015-08-13 23:56:22 GMT)
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CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
option 3: inactivation of a gene
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
cccccccccccccccccccccccccccc
Gene knockout: loss of a gene can be compensated by another gene
http://www.mpg.de/9331068/knockout-knockdown
ccccccccccccccccccccc
A knockout mouse or knock-out mouse is a genetically modified mouse in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity often causes changes in a mouse's phenotype, which includes appearance, behavior and other observable physical and biochemical characteristics.
The loss of gene activity often causes changes in a mouse's phenotype, which includes appearance, behavior and other observable physical and biochemical
https://en.wikipedia.org/wiki/Knockout_mouse
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What is a knockout mouse?
A knockout mouse is a laboratory mouse in which researchers have inactivated, or "knocked out," an existing gene by replacing it or disrupting it with an artificial piece of DNA. The loss of gene activity often causes changes in a mouse's phenotype, which includes appearance, behavior and other observable physical and biochemical characteristics.
https://www.genome.gov/12514551
Note from asker:
| Thank you all for advice and your suggestions. I've decided to go with the 'gene knockout', but since this suggestion of mine was approved of (and not proposed) by others, I'm not sure how am I supposed to arrange points here... |
| *assign, not arrange.. Where's the coffee? ;) |
Peer comment(s):
| agree |
mike23
: 'gene knockout' seems to be a popular term; 'removal of a gene' is used too
2 hrs
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Thank you, Michał. Knockout is a better choice, but check my links.
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| agree |
Izabela Czartoryska
: in this context 'gene knockout' or 'gene inactivation' - yes, 'loss of a gene' - not
1 day 33 mins
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Dziękuję Izabelo za pomoc.
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| agree |
Jacek Konopka
1 day 16 hrs
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Thank you, Jacek. May all your mornings be bright! Take care and carry on.
|
4 KudoZ points awarded for this answer.
Comment: "Thanks a lot (again)!"
14 mins
lacking the gene
.
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Note added at 17 mins (2015-08-13 15:09:19 GMT)
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Handbook of Multiple Sclerosis, Third Edition
https://books.google.co.uk/books?isbn=0824741846
Stuart D. Cook - 2001 - Medical
Histological examination of the spinal cord demonstrated a lack of ... disease when compared with mice infected with a control construct lacking the PLP gene.
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Note added at 17 mins (2015-08-13 15:09:19 GMT)
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Handbook of Multiple Sclerosis, Third Edition
https://books.google.co.uk/books?isbn=0824741846
Stuart D. Cook - 2001 - Medical
Histological examination of the spinal cord demonstrated a lack of ... disease when compared with mice infected with a control construct lacking the PLP gene.
Discussion
@Kama_Wawa
1) Stick with knock-out alone, close the question, and not award points.
2) Stick with knock-out and my addition of inactivation and award me points, in which case I would change the glossary entry to knock-out (inactivation).
https://www.google.pl/#q="gene knockout"
https://www.google.pl/#q="removal of a gene" knockout