English to Russian Medical Medical: Pharmaceuticals

Disability progression across the spectrum of MS might occur because of 2 concurrent inflammatory mechanisms: acute inflammation and chronic compartmentalized inflammation.
Pathophysiologically, relapsing forms of MS (i.e., RMS) are associated with focal T cell and B cell invasion, with blood-brain barrier leakage that gives rise to classic active demyelinating plaques in white matter.
However, RMS also harbors signs of progression biology/chronic compartmentalized inflammation.
By contrast to these acute inflammatory processes, chronic compartmentalized inflammation is responsible for an increase in disability that occurs independently from relapses or radiological disease activity and is characterized by demyelination and axonal loss (progression biology; Lassmann 2019).