Jan 4, 2011 15:54
13 yrs ago
1 viewer *
English term
Italy
BTB (Bric-a-brac, Tramtrack, Broad-complex) domain
English to Italian
Medical
Manufacturing
Ubiquitination requires coordinated action of a Ub-activating
enzyme (E1), a Ub-conjugating enzyme (E2), and a Ub ligase
(E3). Cullin-RING ligases (CRLs) comprise the largest group of
E3 enzymes in eukaryotes (Bosu and Kipreos, 2008; Petroski
and Deshaies, 2005). CRLs, including CUL3, operate as multisubunit
complexes that contain a cullin, a RING H2 finger protein,
and a substrate-binding moiety. CUL3 typically connects the
RING H2 finger protein Ring-box (RBX) 1 or 2 and a substratebinding
subunit containing a BTB (Bric-a-brac, Tramtrack,
Broad-complex) domain (Bosu and Kipreos, 2008).
enzyme (E1), a Ub-conjugating enzyme (E2), and a Ub ligase
(E3). Cullin-RING ligases (CRLs) comprise the largest group of
E3 enzymes in eukaryotes (Bosu and Kipreos, 2008; Petroski
and Deshaies, 2005). CRLs, including CUL3, operate as multisubunit
complexes that contain a cullin, a RING H2 finger protein,
and a substrate-binding moiety. CUL3 typically connects the
RING H2 finger protein Ring-box (RBX) 1 or 2 and a substratebinding
subunit containing a BTB (Bric-a-brac, Tramtrack,
Broad-complex) domain (Bosu and Kipreos, 2008).
Reference comments
12 mins
Reference:
The "BTB/POZ domain" is a term that defines a pretty common and important class of genes/proteins, apparently first discussed in O. Albagli et al., "The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding protein", Cell Growth Differ 6 (9), 1193-8, 1995, which says:
The BTB (3) (for Broad Complex, tramtrack and bric à brac) or POZ (4) (for poxviruses and zinc finger) is an approximately 120-amino acid conserved and hydrophobic domain present generally at the NH2-terminal end of numerous proteins including Zinc finger, poxvirus, and actin-binding proteins.
http://itre.cis.upenn.edu/~myl/languagelog/archives/004732.h...
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Note added at 16 min (2011-01-04 16:10:40 GMT)
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direi comunque *dominio BTB*
http://www.ricercaitaliana.it/prin/unita_op-2007Y4ZAL3_004.h...
The BTB (3) (for Broad Complex, tramtrack and bric à brac) or POZ (4) (for poxviruses and zinc finger) is an approximately 120-amino acid conserved and hydrophobic domain present generally at the NH2-terminal end of numerous proteins including Zinc finger, poxvirus, and actin-binding proteins.
http://itre.cis.upenn.edu/~myl/languagelog/archives/004732.h...
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Note added at 16 min (2011-01-04 16:10:40 GMT)
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direi comunque *dominio BTB*
http://www.ricercaitaliana.it/prin/unita_op-2007Y4ZAL3_004.h...
2 hrs
Reference:
*dominio BTB* come dice Valeria
Many human genes were first described by geneticists who identified counterpart genes in the laboratory fruitfly. Fruitfly researchers consider it a matter of pride to give genes colorful names, but these are often moderated or disguised by medical researchers who feel absurd names will not help attract research funds. BTBD9, the gene in today's two studies, stands for broad complex-tramtrack-bric-a-brac-domain 9.
http://webcache.googleusercontent.com/search?q=cache:cVkgPTw...
http://webcache.googleusercontent.com/search?q=cache:cVkgPTw...
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