Glossary entry (derived from question below)
English term or phrase:
Half-maximal concentration
French translation:
la concentration inhibitrice 50 (CI50)
English term
Half-maximal
Il s'agit de tests de cytotoxicité qui mesurent l'activité de la lignée p53 (cellules du cancer du côlon)
J'aimerais savoir quelle est la traduction d'usage pour "half-maximal"
merci!
Oct 3, 2007 12:09: Diane de Cicco Created KOG entry
Proposed translations
France
Specialty: Biology, Chemistry, Medicine
Native in: English 
, French
Works in: English to French, French to English
la concentration inhibitrice 50%
http://medidacte.timone.univ-mrs.fr/Learnet/webcours/med_travail/cytotoxicologie/chap7.htm
| Merci Diane et tous les autres qui ont appuyé! |
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GILLES MEUNIER
33 mins
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Merci
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Eric BILLY
: oui mais attention, le terme exacte est: la concentration inhibitrice 50 / et non 50%
1 hr
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Oui, merci, effectivement bien que 50 % soit parfois utilisé aussi
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Drmanu49
: Hi SDDC!
2 hrs
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Hi SDrManu49, thank you
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Catherine GUILLIAUMET
: Oui, c'est la CI50 (50 étant écrit en indice)
3 hrs
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Exact, merci
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United States
Translating into native U.S. English
Native in: English 
Works in: Portuguese to English, Spanish to English
demi-maximal
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Note added at 7 mins (2007-10-02 02:27:02 GMT)
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demi-maximale
http://www.wipo.int/pctdb/en/wo.jsp?wo=1989001945
| Merci d'avoir contribué! |
PhD with a solid scientific background
Native in: French (Variants: Belgian, Standard-France)
Works in: English to French, French to English
La concentration qui inhibe 50% de l'activité
L'activité inhibitrice peut être exprimée sous la forme de la constante d'inhibition (Ki) ou de la concentration inhibant 50 % de l'activité (CI50).
http://www.hc-sc.gc.ca/dhp-mps/prodpharma/applic-demande/guide-ld/interactions/drug_medi_int_f.html
| Merci Isabelle, vos contributions sont toujours appréciées. |
Discussion
In this study, researchers compared the cell growth inhibitory potential of the four compounds on the p53 wild type human colon cancer cell line 40-16 (p53(+/+)) and its p53 knockout derivative 379.2 (p53(-/-)) (both derived from HCT116). [...] Half-maximal inhibitory concentrations of all four compounds in both cell lines ranged from 5-15 microM after 24, 48 and 72 h of treatment. Apoptosis induction was analyzed by immunoblotting of poly (ADP-ribose) polymerase (PARP). Treatment with sulforaphane (15 microM), PEITC (10 microM), indole-3-carbinol (10 microM) and 3,3'- diindolylmethane (10 microM) induced PARP cleavage after 24 and 48 h in both 40-16 and the 379.2 cell lines, suggestive of a p53-independent mechanism of apoptosis induction.