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Spinal ERK pathway

Dutch translation: ERK-signaaltransductieroute in het ruggenmerg

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:Spinal ERK pathway
Dutch translation:ERK-signaaltransductieroute in het ruggenmerg
Entered by: Barend van Zadelhoff

18:11 Dec 22, 2014
English to Dutch translations [PRO]
Science - Biology (-tech,-chem,micro-) / Biology
English term or phrase: Spinal ERK pathway
Context:

Using a mouse model of neuropathic pain, researchers discovered that injections of bergamot or linalool (a main chemical constituent of bergamot) provided reduction of pain symptoms by inhibiting phosphorylation of the spinal ERK pathway
Marloes van Beveren
Mexico
ERK-signaaltransductieroute in het ruggenmerg
Explanation:
In zoogdieren zijn tot op heden 14 mapk-genen geïdentificeerd. Eén van de best gekarakteriseerde MAPK-signaaltransductiemodules is die van de Extracellular signal-Regulated Kinases 1 en (ERK1/ERK2). De belangrijkste doelstelling van de studie die in dit proefschrift wordt beschreven, is het begrijpen van het activeringsmechanisme en de functie van ERK1 en ERK2 tijdens ontwikkelingsprocessen, zoals celmigratie en celdifferentiatie. Om de activering en functie van ERK1 en ERK2 te onderzoeken hebben wij gebruik gemaakt van embryonale zebraviscelculturen en zebravisembryo’s.

Uit onze resultaten bleek dat stimulatie van gekweekte zebraviscellen met CO’s leidt tot een transiente activatie van ERK1 en ERK2, met een maximum dat bereikt werd 15 minuten na toediening. Daarnaast hebben wij ook de signaaltransductieroute die leidt tot activatie van ERK1 en ERK2 door COstimulatie bestudeerd. Wij concluderen dat er een receptorsysteem met een hoge affiniteit voor dit oligosaccharide moet bestaan, dat na binding een signaal doorgeeft via de ERK-signaaltransductieroute, bestaande uit RAF, MEK en ERK.

https://openaccess.leidenuniv.nl/bitstream/handle/1887/12348...

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Note added at 57 mins (2014-12-22 19:08:49 GMT)
--------------------------------------------------

Here you can see that this pathway can be manipulated at spinal and supraspinal level:

Extracellular signal-regulated kinase (ERK), a mitogen-activated protein kinases (MAPK), transduces a broad range of extracellular stimuli into diverse intracellular responses. Recent studies have showed that ERK activation in the supraspinal level iis involved in the development of drug dependence, especially in psychological dependence.
In this study, we reported that the spinal ERK signaling pathway was activated by chronic morphine injection. There was a further increase in ERK activation after naloxone-precipitated withdrawal. Furthermore, attenuation of the spinal ERK phosphorylation by intrathecal a MAPK kinase (MEK) inhibitor U0126 or knockdown of the spinal ERK by antisense oligonucleotides not only decreased the scores of morphine withdrawal, but also attenuated withdrawal-induced allodynia, which were accompanied by decreased ERK phosphorylation in the spinal cord.

http://www.sciencedirect.com/science/article/pii/S0304395905...


--------------------------------------------------
Note added at 1 hr (2014-12-22 19:45:42 GMT)
--------------------------------------------------

Another two related links:

The ERK Signal Transduction Pathway

http://www.rndsystems.com/mini_review_detail_objectname_MR04...

The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.

http://en.wikipedia.org/wiki/MAPK/ERK_pathway

--------------------------------------------------
Note added at 1 day22 hrs (2014-12-24 16:47:54 GMT) Post-grading
--------------------------------------------------

Merry Christmas, Marloes. :-)
Selected response from:

Barend van Zadelhoff
Netherlands
Local time: 09:01
Grading comment
Veel dank!
4 KudoZ points were awarded for this answer



Summary of answers provided
3ERK-signaaltransductieroute in het ruggenmerg
Barend van Zadelhoff


  

Answers


41 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
spinal ERK pathway
ERK-signaaltransductieroute in het ruggenmerg


Explanation:
In zoogdieren zijn tot op heden 14 mapk-genen geïdentificeerd. Eén van de best gekarakteriseerde MAPK-signaaltransductiemodules is die van de Extracellular signal-Regulated Kinases 1 en (ERK1/ERK2). De belangrijkste doelstelling van de studie die in dit proefschrift wordt beschreven, is het begrijpen van het activeringsmechanisme en de functie van ERK1 en ERK2 tijdens ontwikkelingsprocessen, zoals celmigratie en celdifferentiatie. Om de activering en functie van ERK1 en ERK2 te onderzoeken hebben wij gebruik gemaakt van embryonale zebraviscelculturen en zebravisembryo’s.

Uit onze resultaten bleek dat stimulatie van gekweekte zebraviscellen met CO’s leidt tot een transiente activatie van ERK1 en ERK2, met een maximum dat bereikt werd 15 minuten na toediening. Daarnaast hebben wij ook de signaaltransductieroute die leidt tot activatie van ERK1 en ERK2 door COstimulatie bestudeerd. Wij concluderen dat er een receptorsysteem met een hoge affiniteit voor dit oligosaccharide moet bestaan, dat na binding een signaal doorgeeft via de ERK-signaaltransductieroute, bestaande uit RAF, MEK en ERK.

https://openaccess.leidenuniv.nl/bitstream/handle/1887/12348...

--------------------------------------------------
Note added at 57 mins (2014-12-22 19:08:49 GMT)
--------------------------------------------------

Here you can see that this pathway can be manipulated at spinal and supraspinal level:

Extracellular signal-regulated kinase (ERK), a mitogen-activated protein kinases (MAPK), transduces a broad range of extracellular stimuli into diverse intracellular responses. Recent studies have showed that ERK activation in the supraspinal level iis involved in the development of drug dependence, especially in psychological dependence.
In this study, we reported that the spinal ERK signaling pathway was activated by chronic morphine injection. There was a further increase in ERK activation after naloxone-precipitated withdrawal. Furthermore, attenuation of the spinal ERK phosphorylation by intrathecal a MAPK kinase (MEK) inhibitor U0126 or knockdown of the spinal ERK by antisense oligonucleotides not only decreased the scores of morphine withdrawal, but also attenuated withdrawal-induced allodynia, which were accompanied by decreased ERK phosphorylation in the spinal cord.

http://www.sciencedirect.com/science/article/pii/S0304395905...


--------------------------------------------------
Note added at 1 hr (2014-12-22 19:45:42 GMT)
--------------------------------------------------

Another two related links:

The ERK Signal Transduction Pathway

http://www.rndsystems.com/mini_review_detail_objectname_MR04...

The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.

http://en.wikipedia.org/wiki/MAPK/ERK_pathway

--------------------------------------------------
Note added at 1 day22 hrs (2014-12-24 16:47:54 GMT) Post-grading
--------------------------------------------------

Merry Christmas, Marloes. :-)

Barend van Zadelhoff
Netherlands
Local time: 09:01
Native speaker of: Native in DutchDutch
PRO pts in category: 32
Grading comment
Veel dank!
Notes to answerer
Asker: Insgelijks!

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