disulfide bond scrambling

12:14 Sep 15, 2022
This question was closed without grading. Reason: No acceptable answer

English to Serbian translations [PRO]
Medical - Medical: Pharmaceuticals / Antibody derivatives
English term or phrase: disulfide bond scrambling
Similarly, Zhang et al. (2010) Anal. Chem. 82: 1090-99 disclose engineering the IgG2 hinge region to limit disulfide bond scrambling and the formation of structural isomers in therapeutic applications.
Svetomir Mijovic
Serbia
Local time: 07:42


Summary of answers provided
3izmena disulfidnih veza
Milan Nesic


  

Answers


56 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
izmena disulfidnih veza


Explanation:
"However, using of a modification at the limited conditions leads to the formation of intermediate products, in which scrambling of disulfide occurs, which are undesirable in the development of pharmaceutical product."

"Korišćenjem limitiranih uslova modifikacije dolazi do izmene disulfida, koji dovode do stvaranja heterogenih intermedijarnih produkata koji su neželjeni u razvoju farmaceutskog produkta."


    https://nardus.mpn.gov.rs/bitstream/handle/123456789/5635/Disertacija3558.pdf
Milan Nesic
Native speaker of: Native in SerbianSerbian
PRO pts in category: 120
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